Column descriptions for files associated with GWAS summary statistics:
GIANT_HEIGHT_YENGO_2022_GWAS_SUMMARY_STATS_[AA|ALL|EAS|EUR|HIS|SAS].gz
Columns are:
SNPID (represented as CHR:POS(hg19):REF:ALT)
RSID
CHR
POS
EFFECT_ALLELE
OTHER_ALLELE
EFFECT_ALLELE_FREQ (rounded to 3 significant figures)
BETA (rounded to 6 significant figures)
SE (rounded to 3 significant figures)
P
N
Note: these files contain results from fixed-effect inverse-variance meta-analyses with 23andMe removed.
Column descriptions for files associated with PGS weights:
GIANT_HEIGHT_YENGO_2022_PGS_WEIGHTS_[AFR|ALL|EAS|EUR|HIS|SAS].gz
Columns are:
SNPID (represented as CHR:POS(hg19):REF:ALT)
RSID
CHR
POS
PGS_EFFECT_ALLELE
PGS_WEIGHT (posterior joint SNP effect)
PGS_OTHER_ALLELE
PGS_POSTERIOR_STANDARD_ERROR (posterior standard deviation of joint SNP effect)
Note: PGS weights were generated using SBayesR implemented with GCTB (v. 2.0) from GWAS summary statistics including data from 23andMe (i.e., based on the largest samples). SBayesR ran with ancestry group matched LD matrix except for the cross-ancestry meta-analysis (i.e., *ALL* file), which is based on an LD matrix estimated in a European ancestry sample.